Assay Detail
Functional
CHEMBL1645733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
5-Non-amino aromatic substituted naphthalimides as potential antitumor agents: Synthesis via Suzuki reaction, antiproliferative activity, and DNA-binding behavior.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.19 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644026 | — | — | 1 | 5.43 |
| CHEMBL1644023 | — | — | 1 | 5.35 |
| CHEMBL1644025 | — | — | 1 | 5.33 |
| CHEMBL1644022 | — | — | 1 | 5.29 |
| CHEMBL1644024 | — | — | 1 | 5.26 |
| CHEMBL70270 | — | — | 1 | 5.22 |
| CHEMBL428676 | AMONAFIDE | 3.0 | 1 | 5.19 |
| CHEMBL1644021 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644026 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1644023 | — | IC50 | = | 4510.0 | nM | 5.35 |
| CHEMBL1644025 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL1644022 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL1644024 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL70270 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL428676 | AMONAFIDE | IC50 | = | 6450.0 | nM | 5.19 |
| CHEMBL1644021 | — | IC50 | = | 36820.0 | nM | 4.43 |