Assay Detail
Functional
CHEMBL1645803
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of autophagy in human H4 cells expressing LC3 using DAPI staining after 4 hrs by fluorescence microscopic analysis
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 47 | 5.49 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644982 | — | — | 1 | 6.55 |
| CHEMBL1644983 | — | — | 1 | 6.54 |
| CHEMBL1644961 | — | — | 1 | 6.54 |
| CHEMBL1644960 | — | — | 1 | 6.19 |
| CHEMBL1644958 | — | — | 1 | 6.01 |
| CHEMBL1644984 | — | — | 1 | 5.92 |
| CHEMBL1644952 | — | — | 1 | 5.68 |
| CHEMBL1644974 | — | — | 1 | 5.66 |
| CHEMBL1644959 | — | — | 1 | 5.66 |
| CHEMBL1644981 | — | — | 1 | 5.62 |
| CHEMBL46516 | FLUSPIRILENE | 3.0 | 1 | 5.62 |
| CHEMBL1644965 | — | — | 1 | 5.58 |
| CHEMBL1644963 | — | — | 1 | 5.58 |
| CHEMBL1644978 | — | — | 1 | 5.57 |
| CHEMBL1644956 | — | — | 1 | 5.51 |
| CHEMBL47050 | PENFLURIDOL | 2.0 | 1 | 5.50 |
| CHEMBL371031 | — | — | 1 | 5.50 |
| CHEMBL1644955 | — | — | 1 | 5.43 |
| CHEMBL1644954 | — | — | 1 | 5.38 |
| CHEMBL1644976 | — | — | 1 | 5.37 |
| CHEMBL1644973 | — | — | 1 | 5.36 |
| CHEMBL1644979 | — | — | 1 | 5.35 |
| CHEMBL1644957 | — | — | 1 | 5.34 |
| CHEMBL1644951 | — | — | 1 | 5.33 |
| CHEMBL240870 | — | — | 1 | 5.29 |
| CHEMBL1644980 | — | — | 1 | 5.29 |
| CHEMBL1644947 | — | — | 1 | 5.21 |
| CHEMBL1644972 | — | — | 1 | 5.19 |
| CHEMBL240869 | — | — | 1 | 5.10 |
| CHEMBL1644975 | — | — | 1 | 4.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644982 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL1644983 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1644961 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1644960 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1644958 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL1644984 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1644952 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1644974 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1644959 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1644981 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL46516 | FLUSPIRILENE | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1644965 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1644963 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1644978 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1644956 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL47050 | PENFLURIDOL | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL371031 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL1644955 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1644954 | — | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1644976 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1644973 | — | EC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1644979 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1644957 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1644951 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1644980 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL240870 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1644947 | — | EC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1644972 | — | EC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL240869 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL1644975 | — | EC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1644964 | — | EC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL1644945 | — | EC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1644946 | — | EC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL1644953 | — | EC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL1644962 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644948 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL84542 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644966 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL267930 | SPIPERONE | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644977 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644967 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644949 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644968 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644950 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644969 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644970 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL1644971 | — | EC50 | > | 50000.0 | nM | - |