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Assay Detail

CHEMBL1645873

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Autocuration

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Virtual screening and synthesis of quinazolines as novel JAK2 inhibitors.
Yang SH, Khadka DB, Cho SH, Ju HK, Lee KY, Han HJ, Lee KT, Cho WJ.
Bioorg Med Chem (2011) 19 : 968 -977
PubMed 21185195 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.44 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1641774 1 5.10
CHEMBL1641775 1 4.36
CHEMBL555201 1 4.29
CHEMBL1641778 1 4.00
CHEMBL1641776 1 -
CHEMBL1641777 1 -
CHEMBL1641780 1 -
CHEMBL1641781 1 -
CHEMBL1641782 1 -
CHEMBL1641773 1 -
CHEMBL1641771 1 -
CHEMBL1641772 1 -
CHEMBL56543 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1641774 IC50 = 8019.0 nM 5.10
CHEMBL1641775 IC50 = 43946.0 nM 4.36
CHEMBL555201 IC50 = 51472.0 nM 4.29
CHEMBL1641778 IC50 = 99547.0 nM 4.00
CHEMBL1641776 IC50 > 100000.0 nM -
CHEMBL1641777 IC50 > 100000.0 nM -
CHEMBL1641780 IC50 > 100000.0 nM -
CHEMBL1641781 IC50 > 100000.0 nM -
CHEMBL1641782 IC50 > 100000.0 nM -
CHEMBL1641773 IC50 > 100000.0 nM -
CHEMBL1641771 IC50 > 100000.0 nM -
CHEMBL1641772 IC50 > 100000.0 nM -
CHEMBL56543 IC50 > 100000.0 nM -