Assay Detail
Binding
CHEMBL1646233
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Inhibition of NET
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.36 | 7.36 |
| IC50 | 2 | 5.76 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173861 | — | — | 1 | 7.36 |
| CHEMBL1643896 | — | — | 1 | 5.76 |
| CHEMBL1643897 | — | — | 1 | - |
| CHEMBL1214060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173861 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL1643896 | — | IC50 | = | 1728.0 | nM | 5.76 |
| CHEMBL1643897 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL1214060 | — | IC50 | > | 1000.0 | nM | - |