Assay Detail
Binding
CHEMBL1646368
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Inhibition of recombinant SHP1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.38 | 4.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | — | 1 | 4.56 |
| CHEMBL1756 | ESTRAMUSTINE PHOSPHATE | 4.0 | 1 | 4.39 |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 4.18 |
| CHEMBL1642763 | ESTRADIOL PHOSPHATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301982 | CELASTROL | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL1756 | ESTRAMUSTINE PHOSPHATE | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL230006 | ENOXOLONE | IC50 | = | 65400.0 | nM | 4.18 |
| CHEMBL1642763 | ESTRADIOL PHOSPHATE | IC50 | > | 300000.0 | nM | - |