Assay Detail
Binding
CHEMBL1646404
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-ditolyl guanidine from sigma 2 receptor in rat PC12 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | PC-12 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.57 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643900 | — | — | 1 | 8.22 |
| CHEMBL1643899 | — | — | 1 | 7.72 |
| CHEMBL1643902 | — | — | 1 | 7.41 |
| CHEMBL1643901 | — | — | 1 | 6.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643900 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1643899 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL1643902 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL1643901 | — | Ki | = | 117.0 | nM | 6.93 |