Assay Detail
Binding
CHEMBL1646406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nisoxetine from human NET expressed in HEK cells
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Trishomocubane as a scaffold for the development of selective dopamine transporter (DAT) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 2 | - | - |
| Ki | 2 | 5.34 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643900 | — | — | 1 | 5.44 |
| CHEMBL1643899 | — | — | 1 | 5.23 |
| CHEMBL1643901 | — | — | 1 | - |
| CHEMBL1643902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643900 | — | Ki | = | 3623.0 | nM | 5.44 |
| CHEMBL1643899 | — | Ki | = | 5883.0 | nM | 5.23 |
| CHEMBL1643901 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL1643902 | — | Inhibition | < | 50.0 | % | - |