Assay Detail
Functional
CHEMBL1646463
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Cytotoxicity against human KB cells after 72 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of antiproliferative flavones from calycopterin, major flavonoid of Calycopteris floribunda Lamk.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.58 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18351 | — | — | 1 | 8.10 |
| CHEMBL1643903 | — | — | 1 | 7.60 |
| CHEMBL1643916 | — | — | 1 | 7.11 |
| CHEMBL1643915 | — | — | 1 | 6.89 |
| CHEMBL504047 | 5-HYDROXYAURANETIN | — | 1 | 6.14 |
| CHEMBL1643920 | — | — | 1 | 5.21 |
| CHEMBL1643918 | — | — | 1 | 5.00 |
| CHEMBL1643919 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18351 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1643903 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1643916 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL1643915 | — | IC50 | = | 128.0 | nM | 6.89 |
| CHEMBL504047 | 5-HYDROXYAURANETIN | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1643920 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL1643918 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1643919 | — | IC50 | > | 10000.0 | nM | - |