Assay Detail
Binding
CHEMBL1646509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]ditolylguanidine from sigma2 receptor in rat liver membrane by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ(1) receptor ligands with a (2-fluoroethyl) residue in 3-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.66 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1645207 | — | — | 1 | 7.24 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL1645215 | — | — | 1 | 7.09 |
| CHEMBL1645214 | — | — | 1 | 6.93 |
| CHEMBL1645209 | — | — | 1 | 6.38 |
| CHEMBL1645205 | — | — | 1 | 6.32 |
| CHEMBL1645202 | — | — | 1 | 6.11 |
| CHEMBL1645212 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1645207 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL1645215 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL1645214 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL1645209 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL1645205 | — | Ki | = | 481.0 | nM | 6.32 |
| CHEMBL1645202 | — | Ki | = | 785.0 | nM | 6.11 |
| CHEMBL1645212 | — | Ki | = | 878.0 | nM | 6.06 |