Assay Detail
Binding
CHEMBL1646521
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Inhibition of beta-lactamase TEM-1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modifications of the C6-substituent of penicillin sulfones with the goal of improving inhibitor recognition and efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.84 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1645238 | — | — | 1 | 7.92 |
| CHEMBL1645237 | — | — | 1 | 6.75 |
| CHEMBL1645359 | — | — | 1 | 6.35 |
| CHEMBL1645239 | — | — | 1 | 5.92 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 5.89 |
| CHEMBL1645363 | — | — | 1 | 5.21 |
| CHEMBL1645232 | — | — | 1 | 5.08 |
| CHEMBL1645360 | — | — | 1 | 5.00 |
| CHEMBL1645240 | — | — | 1 | 4.46 |
| CHEMBL1645231 | — | — | 1 | - |
| CHEMBL1645233 | — | — | 1 | - |
| CHEMBL1645234 | — | — | 1 | - |
| CHEMBL1645235 | — | — | 1 | - |
| CHEMBL1645236 | — | — | 1 | - |
| CHEMBL1645355 | — | — | 1 | - |
| CHEMBL1645356 | — | — | 1 | - |
| CHEMBL1645357 | — | — | 1 | - |
| CHEMBL1645358 | — | — | 1 | - |
| CHEMBL1645361 | — | — | 1 | - |
| CHEMBL1645362 | — | — | 1 | - |
| CHEMBL1645364 | — | — | 1 | - |
| CHEMBL1645365 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1645238 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1645237 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1645359 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1645239 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL403 | SULBACTAM | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1645363 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL1645232 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL1645360 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1645240 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1645231 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645233 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645234 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645235 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645236 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645355 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645356 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645357 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645358 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645361 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645362 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645364 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1645365 | — | IC50 | > | 50000.0 | nM | - |