Assay Detail
Binding
CHEMBL1646830
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of yeast glutathione reductase by spectrophotometry
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutathione reductase (CHEMBL4119) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.55 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1614664 | PSEUDOHYPERICIN | — | 1 | 5.66 |
| CHEMBL286494 | HYPERICIN | 3.0 | 1 | 5.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1614664 | PSEUDOHYPERICIN | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL286494 | HYPERICIN | IC50 | = | 3670.0 | nM | 5.43 |