Assay Detail
Binding
CHEMBL1646987
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Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.59 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643298 | — | — | 1 | 8.68 |
| CHEMBL1643301 | — | — | 1 | 8.62 |
| CHEMBL1615280 | — | — | 1 | 8.48 |
| CHEMBL1643307 | — | — | 1 | 8.05 |
| CHEMBL1643303 | — | — | 1 | 8.01 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL1614844 | — | — | 1 | 7.82 |
| CHEMBL316779 | — | — | 1 | 7.30 |
| CHEMBL1643300 | — | — | 1 | 7.19 |
| CHEMBL1643293 | — | — | 1 | 7.12 |
| CHEMBL1643302 | — | — | 1 | 7.07 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 7.02 |
| CHEMBL1615215 | — | — | 1 | 6.65 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.62 |
| CHEMBL1446150 | — | — | 1 | 6.11 |
| CHEMBL1643305 | — | — | 1 | 6.04 |
| CHEMBL1643295 | — | — | 1 | 5.97 |
| CHEMBL1337519 | — | — | 1 | 5.94 |
| CHEMBL1643291 | — | — | 1 | 5.89 |
| CHEMBL1643306 | — | — | 1 | 5.75 |
| CHEMBL1643289 | — | — | 1 | 5.66 |
| CHEMBL1643297 | — | — | 1 | 5.61 |
| CHEMBL1643292 | — | — | 1 | 5.58 |
| CHEMBL1643304 | — | — | 1 | 5.48 |
| CHEMBL25600 | — | — | 1 | 5.43 |
| CHEMBL1643290 | — | — | 1 | 5.43 |
| CHEMBL1643294 | — | — | 1 | 5.39 |
| CHEMBL1643296 | — | — | 1 | 5.30 |
| CHEMBL1643299 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643298 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1643301 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1615280 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL1643307 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL1643303 | — | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL1614844 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL316779 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL1643300 | — | Ki | = | 64.7 | nM | 7.19 |
| CHEMBL1643293 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL1643302 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL1615215 | — | Ki | = | 226.0 | nM | 6.65 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL1446150 | — | Ki | = | 781.0 | nM | 6.11 |
| CHEMBL1643305 | — | Ki | = | 908.0 | nM | 6.04 |
| CHEMBL1643295 | — | Ki | = | 1060.0 | nM | 5.97 |
| CHEMBL1337519 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL1643291 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL1643306 | — | Ki | = | 1765.0 | nM | 5.75 |
| CHEMBL1643289 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL1643297 | — | Ki | = | 2485.0 | nM | 5.61 |
| CHEMBL1643292 | — | Ki | = | 2634.0 | nM | 5.58 |
| CHEMBL1643304 | — | Ki | = | 3310.0 | nM | 5.48 |
| CHEMBL25600 | — | Ki | = | 3730.0 | nM | 5.43 |
| CHEMBL1643290 | — | Ki | = | 3725.0 | nM | 5.43 |
| CHEMBL1643294 | — | Ki | = | 4070.0 | nM | 5.39 |
| CHEMBL1643296 | — | Ki | = | 5005.0 | nM | 5.30 |
| CHEMBL1643299 | — | Ki | = | 9600.0 | nM | 5.02 |