Assay Detail
Binding
CHEMBL1646989
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Inhibition of Mycobacterium tuberculosis recombinant beta-carbonic anhydrase Rv1284 preincubated for 15 mins by stopped-flow CO2 hydrase assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Beta-carbonic anhydrase 1 (CHEMBL5631) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Inhibition of β-carbonic anhydrases with ureido-substituted benzenesulfonamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.58 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1446150 | — | — | 1 | 8.32 |
| CHEMBL316779 | — | — | 1 | 8.30 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 8.19 |
| CHEMBL1643292 | — | — | 1 | 8.17 |
| CHEMBL1643291 | — | — | 1 | 8.12 |
| CHEMBL1643298 | — | — | 1 | 7.45 |
| CHEMBL1643304 | — | — | 1 | 7.31 |
| CHEMBL1643300 | — | — | 1 | 7.30 |
| CHEMBL1643293 | — | — | 1 | 7.18 |
| CHEMBL1614844 | — | — | 1 | 7.17 |
| CHEMBL1337519 | — | — | 1 | 7.16 |
| CHEMBL1643306 | — | — | 1 | 6.50 |
| CHEMBL25600 | — | — | 1 | 6.45 |
| CHEMBL1643289 | — | — | 1 | 6.36 |
| CHEMBL1643294 | — | — | 1 | 6.33 |
| CHEMBL1643295 | — | — | 1 | 6.33 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.32 |
| CHEMBL1643307 | — | — | 1 | 6.31 |
| CHEMBL1615215 | — | — | 1 | 6.29 |
| CHEMBL1643301 | — | — | 1 | 6.27 |
| CHEMBL1643302 | — | — | 1 | 6.25 |
| CHEMBL1643305 | — | — | 1 | 6.14 |
| CHEMBL1643290 | — | — | 1 | 5.36 |
| CHEMBL1643297 | — | — | 1 | 5.32 |
| CHEMBL1643303 | — | — | 1 | 5.25 |
| CHEMBL1643296 | — | — | 1 | 5.25 |
| CHEMBL1615280 | — | — | 1 | 5.25 |
| CHEMBL1643299 | — | — | 1 | 5.19 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1446150 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL316779 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL1643292 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL1643291 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL1643298 | — | Ki | = | 35.2 | nM | 7.45 |
| CHEMBL1643304 | — | Ki | = | 49.1 | nM | 7.31 |
| CHEMBL1643300 | — | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL1643293 | — | Ki | = | 65.7 | nM | 7.18 |
| CHEMBL1614844 | — | Ki | = | 67.1 | nM | 7.17 |
| CHEMBL1337519 | — | Ki | = | 69.3 | nM | 7.16 |
| CHEMBL1643306 | — | Ki | = | 315.0 | nM | 6.50 |
| CHEMBL25600 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL1643289 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL1643294 | — | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL1643295 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 481.0 | nM | 6.32 |
| CHEMBL1643307 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL1615215 | — | Ki | = | 509.0 | nM | 6.29 |
| CHEMBL1643301 | — | Ki | = | 534.0 | nM | 6.27 |
| CHEMBL1643302 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL1643305 | — | Ki | = | 728.0 | nM | 6.14 |
| CHEMBL1643290 | — | Ki | = | 4330.0 | nM | 5.36 |
| CHEMBL1643297 | — | Ki | = | 4760.0 | nM | 5.32 |
| CHEMBL1643303 | — | Ki | = | 5590.0 | nM | 5.25 |
| CHEMBL1643296 | — | Ki | = | 5690.0 | nM | 5.25 |
| CHEMBL1615280 | — | Ki | = | 5610.0 | nM | 5.25 |
| CHEMBL1643299 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 9230.0 | nM | 5.04 |