Assay Detail
Binding
CHEMBL1647079
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Inhibition of human 11beta-HSD1 expressed in CHO cells after 3 hrs by HTRF cortisol assay
32
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL4235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and 11β hydroxysteroid dehydrogenase 1 inhibition of thiazolidine derivatives with an adamantyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.30 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642841 | — | — | 2 | 8.70 |
| CHEMBL1642622 | — | — | 4 | 8.52 |
| CHEMBL1642618 | — | — | 1 | 8.30 |
| CHEMBL1642620 | — | — | 1 | 8.10 |
| CHEMBL1642843 | — | — | 1 | 8.00 |
| CHEMBL1642608 | — | — | 1 | 8.00 |
| CHEMBL1642613 | — | — | 1 | 8.00 |
| CHEMBL1642614 | — | — | 1 | 8.00 |
| CHEMBL1642615 | — | — | 1 | 8.00 |
| CHEMBL1642624 | — | — | 1 | 7.96 |
| CHEMBL1642623 | — | — | 1 | 7.96 |
| CHEMBL1642840 | — | — | 2 | 7.92 |
| CHEMBL1642621 | — | — | 1 | 7.80 |
| CHEMBL1642844 | — | — | 1 | 7.70 |
| CHEMBL1642609 | — | — | 1 | 7.70 |
| CHEMBL1642612 | — | — | 1 | 7.70 |
| CHEMBL1642842 | — | — | 1 | 7.43 |
| CHEMBL1642610 | — | — | 1 | 7.26 |
| CHEMBL1642606 | — | — | 1 | 7.20 |
| CHEMBL1642619 | — | — | 1 | 7.17 |
| CHEMBL1642611 | — | — | 1 | 6.83 |
| CHEMBL1642617 | — | — | 1 | 6.77 |
| CHEMBL499915 | CARBENOXOLONE | 2.0 | 1 | 6.30 |
| CHEMBL1642605 | — | — | 1 | 6.26 |
| CHEMBL1642616 | — | — | 1 | 6.17 |
| CHEMBL1642607 | — | — | 1 | 6.03 |
| CHEMBL1642604 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642841 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1642622 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1642622 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1642622 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1642618 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1642620 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1642843 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1642608 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1642613 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1642614 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1642615 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1642624 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1642623 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1642840 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1642621 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1642844 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1642609 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1642612 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1642842 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1642610 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1642606 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL1642619 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1642611 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL1642617 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL499915 | CARBENOXOLONE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1642605 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL1642616 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL1642607 | — | IC50 | = | 945.0 | nM | 6.03 |
| CHEMBL1642841 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL1642604 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL1642622 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL1642840 | — | IC50 | = | 38700.0 | nM | 4.41 |