Assay Detail
Binding
CHEMBL1647137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and pharmacological evaluation of 4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalenyl amines as triple reuptake inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.56 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642913 | — | — | 1 | 5.82 |
| CHEMBL1642897 | — | — | 1 | 5.80 |
| CHEMBL1642906 | — | — | 1 | 5.79 |
| CHEMBL1642908 | — | — | 1 | 5.70 |
| CHEMBL1642895 | — | — | 1 | 5.63 |
| CHEMBL1642896 | — | — | 1 | 5.28 |
| CHEMBL1642912 | — | — | 1 | 4.88 |
| CHEMBL809 | SERTRALINE | 4.0 | 1 | - |
| CHEMBL1642894 | — | — | 1 | - |
| CHEMBL1642907 | — | — | 1 | - |
| CHEMBL1642914 | — | — | 1 | - |
| CHEMBL1642915 | — | — | 1 | - |
| CHEMBL1642916 | — | — | 1 | - |
| CHEMBL1642917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642913 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL1642897 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1642906 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL1642908 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1642895 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL1642896 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL1642912 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL809 | SERTRALINE | IC50 | - | — | - | |
| CHEMBL1642894 | — | IC50 | - | — | - | |
| CHEMBL1642907 | — | IC50 | - | — | - | |
| CHEMBL1642914 | — | IC50 | - | — | - | |
| CHEMBL1642915 | — | IC50 | - | — | - | |
| CHEMBL1642916 | — | IC50 | - | — | - | |
| CHEMBL1642917 | — | IC50 | - | — | - |