Assay Detail
Binding
CHEMBL1647365
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Binding affinity to mGluR1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.93 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174588 | — | — | 1 | 9.47 |
| CHEMBL1645349 | — | — | 1 | 9.40 |
| CHEMBL1645348 | — | — | 1 | 9.06 |
| CHEMBL1645350 | — | — | 1 | 8.41 |
| CHEMBL1645351 | — | — | 1 | 8.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174588 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL1645349 | — | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL1645348 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL1645350 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL1645351 | — | Ki | = | 4.8 | nM | 8.32 |