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Assay Detail

CHEMBL1647366

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to mouse mGluR1
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Metabotropic glutamate receptor 1 (CHEMBL2892)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Synthesis and evaluation of 6-[1-(2-[(18)F]fluoro-3-pyridyl)-5-methyl-1H-1,2,3-triazol-4-yl]quinoline for positron emission tomography imaging of the metabotropic glutamate receptor type 1 in brain.
Fujinaga M, Yamasaki T, Kawamura K, Kumata K, Hatori A, Yui J, Yanamoto K, Yoshida Y, Ogawa M, Nengaki N, Maeda J, Fukumura T, Zhang MR.
Bioorg Med Chem (2011) 19 : 102 -110
PubMed 21172734 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.85 8.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1645352 1 8.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1645352 IC50 = 1.4 nM 8.85