Assay Detail
Binding
CHEMBL1647667
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Inhibition of ROCK-2 by Immobilized metal ion affinity-based fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.15 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL559147 | Y-27632 | — | 1 | 6.61 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 6.24 |
| CHEMBL1643361 | — | — | 1 | 5.89 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL559147 | Y-27632 | IC50 | = | 245.47 | nM | 6.61 |
| CHEMBL1233300 | HYDROXYFASUDIL | IC50 | = | 575.44 | nM | 6.24 |
| CHEMBL1643361 | — | IC50 | = | 1288.25 | nM | 5.89 |
| CHEMBL38380 | FASUDIL | IC50 | = | 1348.96 | nM | 5.87 |