Assay Detail
Binding
CHEMBL1647669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dofetilide from human ERG
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.02 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643574 | — | — | 1 | 6.10 |
| CHEMBL1643361 | — | — | 1 | 5.50 |
| CHEMBL1233300 | HYDROXYFASUDIL | — | 1 | 5.10 |
| CHEMBL1643368 | — | — | 1 | 4.70 |
| CHEMBL38380 | FASUDIL | 3.0 | 1 | 4.60 |
| CHEMBL559147 | Y-27632 | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643574 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL1643361 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL1233300 | HYDROXYFASUDIL | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL1643368 | — | Ki | = | 19952.62 | nM | 4.70 |
| CHEMBL38380 | FASUDIL | Ki | = | 25118.86 | nM | 4.60 |
| CHEMBL559147 | Y-27632 | Ki | = | 79432.82 | nM | 4.10 |