Assay Detail
Binding
CHEMBL1647727
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Inhibition of human recombinant calmodulin assessed as inhibition of calmodulin-sensitive cAMP phosphodiesterase activation after 15 mins by spectrophotometric analysis
16
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.67 | 5.29 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138649 | 6-HYDROXYFLAVONE | — | 2 | 5.29 |
| CHEMBL50 | QUERCETIN | 3.0 | 2 | 4.89 |
| CHEMBL9352 | NARINGENIN | — | 2 | 4.66 |
| CHEMBL117 | CHRYSIN | — | 2 | 4.48 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | — | 2 | 4.43 |
| CHEMBL294009 | FLAVONOL | — | 2 | 4.26 |
| CHEMBL275638 | FLAVONE | 2.0 | 2 | - |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | - |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138649 | 6-HYDROXYFLAVONE | IC50 | = | 5170.0 | nM | 5.29 |
| CHEMBL50 | QUERCETIN | IC50 | = | 12970.0 | nM | 4.89 |
| CHEMBL9352 | NARINGENIN | IC50 | = | 22010.0 | nM | 4.66 |
| CHEMBL117 | CHRYSIN | IC50 | = | 33430.0 | nM | 4.48 |
| CHEMBL276915 | 7-HYDROXYFLAVONE | IC50 | = | 37100.0 | nM | 4.43 |
| CHEMBL294009 | FLAVONOL | IC50 | = | 55200.0 | nM | 4.26 |
| CHEMBL275638 | FLAVONE | IC50 | = | 102280.0 | nM | - |
| CHEMBL14 | CARBACHOL | IC50 | - | — | - | |
| CHEMBL193 | NIFEDIPINE | IC50 | - | — | - | |
| CHEMBL276915 | 7-HYDROXYFLAVONE | Inhibition | - | % | - | |
| CHEMBL138649 | 6-HYDROXYFLAVONE | Inhibition | - | % | - | |
| CHEMBL294009 | FLAVONOL | Inhibition | - | % | - | |
| CHEMBL275638 | FLAVONE | Inhibition | - | % | - | |
| CHEMBL117 | CHRYSIN | Inhibition | - | % | - | |
| CHEMBL50 | QUERCETIN | Inhibition | - | % | - | |
| CHEMBL9352 | NARINGENIN | Inhibition | - | % | - |