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Assay Detail

CHEMBL1647732

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of calmodulin assessed as inhibition of calmodulin-calcium-PDE4 complex formation
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Calmodulin-1 (CHEMBL6093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Vasorelaxant effect of flavonoids through calmodulin inhibition: Ex vivo, in vitro, and in silico approaches.
Torres-Piedra M, Figueroa M, Hernández-Abreu O, Ibarra-Barajas M, Navarrete-Vázquez G, Estrada-Soto S, Estrada-Soto S.
Bioorg Med Chem (2011) 19 : 542 -546
PubMed 21129983 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.16 4.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL449317 HESPERIDIN 3.0 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL449317 HESPERIDIN IC50 = 70000.0 nM 4.16