Assay Detail
Binding
CHEMBL1647746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]WIN-35428 from human DAT stably expressed in mouse N2A cells by scintillation countnig
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | N2a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.66 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1641691 | — | — | 1 | 8.35 |
| CHEMBL1253735 | — | — | 1 | 7.85 |
| CHEMBL827 | DEXMETHYLPHENIDATE | 4.0 | 1 | 7.60 |
| CHEMBL1641692 | — | — | 1 | 6.44 |
| CHEMBL1641694 | — | — | 1 | 6.29 |
| CHEMBL1641695 | — | — | 1 | 6.18 |
| CHEMBL1641697 | — | — | 1 | 5.95 |
| CHEMBL1641696 | — | — | 1 | 5.69 |
| CHEMBL1641693 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1641691 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL1253735 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL827 | DEXMETHYLPHENIDATE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL1641692 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL1641694 | — | Ki | = | 517.0 | nM | 6.29 |
| CHEMBL1641695 | — | Ki | = | 658.0 | nM | 6.18 |
| CHEMBL1641697 | — | Ki | = | 1112.0 | nM | 5.95 |
| CHEMBL1641696 | — | Ki | = | 2056.0 | nM | 5.69 |
| CHEMBL1641693 | — | Ki | = | 2754.0 | nM | 5.56 |