Assay Detail
Binding
CHEMBL1647762
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Binding affinity to 5HT6 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
1-(Arylsulfonyl)-2,3-dihydro-1H-quinolin-4-one derivatives as 5-HT(6) serotonin receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.40 | 9.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29846 | — | — | 1 | 9.20 |
| CHEMBL431298 | — | — | 1 | 8.90 |
| CHEMBL76237 | — | — | 1 | 8.60 |
| CHEMBL1642114 | — | — | 1 | 8.60 |
| CHEMBL46071 | — | — | 1 | 7.80 |
| CHEMBL433461 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29846 | — | Ki | = | 0.631 | nM | 9.20 |
| CHEMBL431298 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL76237 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL1642114 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL46071 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL433461 | — | Ki | = | 50.12 | nM | 7.30 |