Assay Detail
Binding
CHEMBL1647800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gal4-fused human PPARalpha DNA binding domain expressed in HEK293 cells by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of isoindoline and tetrahydroisoquinoline derivatives as potent, selective PPARδ agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.57 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643201 | — | — | 1 | 5.90 |
| CHEMBL1643200 | — | — | 1 | 5.60 |
| CHEMBL1643199 | — | — | 1 | 5.20 |
| CHEMBL1643194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643201 | — | EC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL1643200 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1643199 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1643194 | — | EC50 | > | 30000.0 | nM | - |