Assay Detail
Binding
CHEMBL1647932
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Inhibition of human recombinant norepinephrine transporter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.99 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642897 | — | — | 1 | 7.14 |
| CHEMBL1643512 | — | — | 1 | 6.86 |
| CHEMBL1643513 | — | — | 1 | 6.22 |
| CHEMBL1643509 | — | — | 1 | 6.03 |
| CHEMBL1643511 | — | — | 1 | 6.03 |
| CHEMBL1643517 | — | — | 1 | 6.00 |
| CHEMBL1643514 | — | — | 1 | 5.93 |
| CHEMBL1643518 | — | — | 1 | 5.90 |
| CHEMBL1643516 | — | — | 1 | 5.73 |
| CHEMBL1641622 | — | — | 1 | 5.73 |
| CHEMBL1643515 | — | — | 1 | 5.59 |
| CHEMBL1643519 | — | — | 1 | 5.51 |
| CHEMBL1643510 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642897 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL1643512 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL1643513 | — | IC50 | = | 601.0 | nM | 6.22 |
| CHEMBL1643509 | — | IC50 | = | 926.0 | nM | 6.03 |
| CHEMBL1643511 | — | IC50 | = | 934.0 | nM | 6.03 |
| CHEMBL1643517 | — | IC50 | = | 1005.0 | nM | 6.00 |
| CHEMBL1643514 | — | IC50 | = | 1184.0 | nM | 5.93 |
| CHEMBL1643518 | — | IC50 | = | 1246.0 | nM | 5.90 |
| CHEMBL1643516 | — | IC50 | = | 1857.0 | nM | 5.73 |
| CHEMBL1641622 | — | IC50 | = | 1849.0 | nM | 5.73 |
| CHEMBL1643515 | — | IC50 | = | 2597.0 | nM | 5.59 |
| CHEMBL1643519 | — | IC50 | = | 3091.0 | nM | 5.51 |
| CHEMBL1643510 | — | IC50 | = | 7141.0 | nM | 5.15 |