Assay Detail
Binding
CHEMBL1647933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant dopamine transporter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent dopamine transporter (CHEMBL238) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 1-(3,4-dichlorophenyl)-N,N-dimethyl-1,2,3,4-tetrahydroquinolin-4-amine, a dual serotonin and dopamine reuptake inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.92 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643513 | — | — | 1 | 8.10 |
| CHEMBL1643512 | — | — | 1 | 7.92 |
| CHEMBL1643514 | — | — | 1 | 7.80 |
| CHEMBL1643511 | — | — | 1 | 7.41 |
| CHEMBL1642897 | — | — | 1 | 7.14 |
| CHEMBL1643518 | — | — | 1 | 7.00 |
| CHEMBL1643516 | — | — | 1 | 6.91 |
| CHEMBL1643517 | — | — | 1 | 6.75 |
| CHEMBL1643509 | — | — | 1 | 6.61 |
| CHEMBL1643519 | — | — | 1 | 6.51 |
| CHEMBL1641622 | — | — | 1 | 6.33 |
| CHEMBL1643515 | — | — | 1 | 6.22 |
| CHEMBL1643510 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643513 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1643512 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1643514 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1643511 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL1642897 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL1643518 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1643516 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL1643517 | — | IC50 | = | 177.0 | nM | 6.75 |
| CHEMBL1643509 | — | IC50 | = | 246.0 | nM | 6.61 |
| CHEMBL1643519 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL1641622 | — | IC50 | = | 465.0 | nM | 6.33 |
| CHEMBL1643515 | — | IC50 | = | 605.0 | nM | 6.22 |
| CHEMBL1643510 | — | IC50 | = | 5033.0 | nM | 5.30 |