Assay Detail
Binding
CHEMBL1648128
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Inhibition of ASK1 assessed as phosphorylated fluorescent peptide by mobility shift assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase 5 (CHEMBL5285) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel ASK1 inhibitors using virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.87 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642655 | — | — | 1 | 7.85 |
| CHEMBL1642656 | — | — | 1 | 7.82 |
| CHEMBL1642657 | — | — | 1 | 7.72 |
| CHEMBL1172777 | — | — | 1 | 4.88 |
| CHEMBL264666 | — | — | 1 | 4.77 |
| CHEMBL1642669 | — | — | 1 | 4.72 |
| CHEMBL269881 | — | — | 1 | 4.60 |
| CHEMBL1410917 | — | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642655 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1642656 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1642657 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1172777 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL264666 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL1642669 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL269881 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL1410917 | — | IC50 | = | 25800.0 | nM | 4.59 |