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Assay Detail

CHEMBL1648260

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAO-A expressed in baculovirus-infected Bacillus thuringiensis israelensis cells after 1 hr by two-step bioluminescent assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors.
Reniers J, Robert S, Frederick R, Masereel B, Vincent S, Wouters J.
Bioorg Med Chem (2011) 19 : 134 -144
PubMed 21183355 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 7.48 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1645547 1 8.44
CHEMBL1645545 1 8.41
CHEMBL1645548 1 8.37
CHEMBL1645544 1 8.30
CHEMBL1645550 1 8.30
CHEMBL1645549 1 7.90
CHEMBL269538 HARMINE 1.0 1 7.77
CHEMBL1645552 1 7.60
CHEMBL14355 1 7.55
CHEMBL1645546 1 7.53
CHEMBL1645553 1 7.45
CHEMBL1645554 1 7.00
CHEMBL1645557 1 6.59
CHEMBL1645551 1 6.30
CHEMBL1645556 1 6.17
CHEMBL1645555 1 5.99

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1645547 Ki = 3.6 nM 8.44
CHEMBL1645545 Ki = 3.9 nM 8.41
CHEMBL1645548 Ki = 4.3 nM 8.37
CHEMBL1645544 Ki = 5.0 nM 8.30
CHEMBL1645550 Ki = 5.0 nM 8.30
CHEMBL1645549 Ki = 12.6 nM 7.90
CHEMBL269538 HARMINE Ki = 16.9 nM 7.77
CHEMBL1645552 Ki = 24.9 nM 7.60
CHEMBL14355 Ki = 28.4 nM 7.55
CHEMBL1645546 Ki = 29.5 nM 7.53
CHEMBL1645553 Ki = 35.4 nM 7.45
CHEMBL1645554 Ki = 100.0 nM 7.00
CHEMBL1645557 Ki = 255.7 nM 6.59
CHEMBL1645551 Ki = 500.0 nM 6.30
CHEMBL1645556 Ki = 684.0 nM 6.17
CHEMBL1645555 Ki = 1023.8 nM 5.99