Assay Detail
Binding
CHEMBL1648481
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Inhibition of ALK by cell based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.14 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642258 | — | — | 1 | 7.52 |
| CHEMBL1642263 | — | — | 1 | 7.40 |
| CHEMBL1642265 | — | — | 1 | 7.40 |
| CHEMBL458997 | — | — | 1 | 7.30 |
| CHEMBL1642260 | — | — | 1 | 7.19 |
| CHEMBL1642261 | — | — | 1 | 7.19 |
| CHEMBL1642264 | — | — | 1 | 7.19 |
| CHEMBL1642257 | — | — | 1 | 7.00 |
| CHEMBL1642262 | — | — | 1 | 7.00 |
| CHEMBL1642253 | — | — | 1 | 6.92 |
| CHEMBL1642255 | — | — | 1 | 6.82 |
| CHEMBL1642254 | — | — | 1 | 6.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642258 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1642263 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1642265 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL458997 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1642260 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1642261 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1642264 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1642257 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1642262 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1642253 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1642255 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1642254 | — | IC50 | = | 175.0 | nM | 6.76 |