Assay Detail
Binding
CHEMBL1648561
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]MCH from human MCHR1 expressed in CHO cells by competition binding assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.89 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1642475 | — | — | 1 | 8.85 |
| CHEMBL179501 | — | — | 1 | 8.85 |
| CHEMBL1642487 | — | — | 1 | 8.42 |
| CHEMBL1642474 | — | — | 1 | 8.38 |
| CHEMBL1642482 | — | — | 1 | 8.36 |
| CHEMBL1642486 | — | — | 1 | 8.29 |
| CHEMBL178707 | — | — | 1 | 8.26 |
| CHEMBL584538 | — | — | 1 | 8.25 |
| CHEMBL1641614 | — | — | 1 | 8.24 |
| CHEMBL1642472 | — | — | 1 | 8.23 |
| CHEMBL1642485 | — | — | 1 | 8.18 |
| CHEMBL1642492 | — | — | 1 | 8.17 |
| CHEMBL1642477 | — | — | 1 | 8.17 |
| CHEMBL1642476 | — | — | 1 | 8.15 |
| CHEMBL1642479 | — | — | 1 | 8.11 |
| CHEMBL1642471 | — | — | 1 | 8.06 |
| CHEMBL1642484 | — | — | 1 | 8.02 |
| CHEMBL1642491 | — | — | 1 | 7.92 |
| CHEMBL1642473 | — | — | 1 | 7.92 |
| CHEMBL1642493 | — | — | 1 | 7.80 |
| CHEMBL1642490 | — | — | 1 | 7.75 |
| CHEMBL1642470 | — | — | 1 | 7.75 |
| CHEMBL1642468 | — | — | 1 | 7.62 |
| CHEMBL1642488 | — | — | 1 | 7.29 |
| CHEMBL1642469 | — | — | 1 | 6.82 |
| CHEMBL1642489 | — | — | 1 | 6.75 |
| CHEMBL1642483 | — | — | 1 | 6.19 |
| CHEMBL1642478 | — | — | 1 | 6.19 |
| CHEMBL1642494 | — | — | 1 | - |
| CHEMBL1642480 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1642475 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL179501 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1642487 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1642474 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL1642482 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL1642486 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL178707 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL584538 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1641614 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1642472 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL1642485 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1642492 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL1642477 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL1642476 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1642479 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL1642471 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL1642484 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL1642491 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1642473 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1642493 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL1642490 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1642470 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1642468 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1642488 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL1642469 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1642489 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1642483 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1642478 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1642494 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1642480 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1642481 | — | IC50 | > | 1000.0 | nM | - |