Assay Detail
Binding
CHEMBL1648623
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Binding affinity to human 5HT3A receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.71 | 10.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643895 | RAMOSETRON | 4.0 | 1 | 10.22 |
| CHEMBL1110 | ALOSETRON | 4.0 | 1 | 9.30 |
| CHEMBL1643884 | — | — | 1 | 9.15 |
| CHEMBL1643894 | — | — | 1 | 9.15 |
| CHEMBL1643893 | — | — | 1 | 9.05 |
| CHEMBL1643887 | — | — | 1 | 8.80 |
| CHEMBL1643883 | — | — | 1 | 8.77 |
| CHEMBL1643886 | — | — | 1 | 8.70 |
| CHEMBL1643885 | — | — | 1 | 8.70 |
| CHEMBL1643889 | — | — | 1 | 8.64 |
| CHEMBL1641625 | — | — | 1 | 8.62 |
| CHEMBL1643888 | — | — | 1 | 8.44 |
| CHEMBL1643881 | — | — | 1 | 8.36 |
| CHEMBL1643882 | — | — | 1 | 8.31 |
| CHEMBL1643890 | — | — | 1 | 8.15 |
| CHEMBL1643892 | — | — | 1 | 8.10 |
| CHEMBL1643891 | — | — | 1 | 7.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643895 | RAMOSETRON | Ki | = | 0.06 | nM | 10.22 |
| CHEMBL1110 | ALOSETRON | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL1643884 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1643894 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1643893 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL1643887 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL1643883 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL1643886 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1643885 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1643889 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1641625 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1643888 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL1643881 | — | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL1643882 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL1643890 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL1643892 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL1643891 | — | Ki | = | 23.4 | nM | 7.63 |