Assay Detail
Functional
CHEMBL1648628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Partial agonist activity at human 5HT3A receptor expressed in HEK293 cells assessed as decrease in 10 uM 5-chloroindole-induced increase in intracellular calcium release
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel serotonin type 3 receptor partial agonists for the potential treatment of irritable bowel syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.68 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1643883 | — | — | 1 | 8.16 |
| CHEMBL1643880 | PUMOSETRAG | 2.0 | 1 | 8.04 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1643883 | — | EC50 | = | 6.9 | nM | 8.16 |
| CHEMBL1643880 | PUMOSETRAG | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL39 | SEROTONIN | EC50 | = | 141.0 | nM | 6.85 |