Assay Detail
Binding
CHEMBL1648826
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Inhibition of recombinant JNK2 after 60 mins by TR-FRET assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.43 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1644646 | — | — | 1 | 7.24 |
| CHEMBL1644638 | — | — | 1 | 7.21 |
| CHEMBL1644618 | — | — | 1 | 7.16 |
| CHEMBL1644615 | — | — | 1 | 7.03 |
| CHEMBL1644639 | — | — | 1 | 7.01 |
| CHEMBL1644642 | — | — | 1 | 7.01 |
| CHEMBL1644625 | — | — | 1 | 6.96 |
| CHEMBL1644619 | — | — | 1 | 6.89 |
| CHEMBL1644641 | — | — | 1 | 6.82 |
| CHEMBL1644637 | — | — | 1 | 6.82 |
| CHEMBL1644645 | — | — | 1 | 6.77 |
| CHEMBL1644632 | — | — | 1 | 6.72 |
| CHEMBL1644622 | — | — | 1 | 6.66 |
| CHEMBL1644620 | — | — | 1 | 6.60 |
| CHEMBL1644640 | — | — | 1 | 6.50 |
| CHEMBL1644621 | — | — | 1 | 6.46 |
| CHEMBL1644635 | — | — | 1 | 6.42 |
| CHEMBL1644623 | — | — | 1 | 6.41 |
| CHEMBL1644630 | — | — | 1 | 6.36 |
| CHEMBL1644624 | — | — | 1 | 6.33 |
| CHEMBL1644643 | — | — | 1 | 6.28 |
| CHEMBL1644636 | — | — | 1 | 6.24 |
| CHEMBL1644627 | — | — | 1 | 6.19 |
| CHEMBL1644634 | — | — | 1 | 6.11 |
| CHEMBL1644626 | — | — | 1 | 6.02 |
| CHEMBL1644629 | — | — | 1 | 5.82 |
| CHEMBL1644644 | — | — | 1 | 5.70 |
| CHEMBL1644631 | — | — | 1 | 5.36 |
| CHEMBL1644633 | — | — | 1 | 5.28 |
| CHEMBL1644617 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1644646 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1644638 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1644618 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1644615 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL1644639 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1644642 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL1644625 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1644619 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1644641 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1644637 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1644645 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1644632 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL1644622 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1644620 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1644640 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1644621 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1644635 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1644623 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1644630 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1644624 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL1644643 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL1644636 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL1644627 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1644634 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL1644626 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL1644629 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1644644 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1644631 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1644633 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1644617 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1644628 | — | IC50 | > | 5000.0 | nM | - |