Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL1648902

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at prostaglandin D2 receptor in human LS174T cells assessed as inhibition of PGD2-induced cAMP accumulation after 15 mins by scintillation proximity assay
ChEMBL ↗
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LS174T
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Prostaglandin D2 receptor (CHEMBL4427) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Understanding DP receptor antagonism using a CoMSIA approach.
Mu L, Aguiar J, Ardati A, Cao B, Gardner CJ, Gillespy T, Harris K, Lim S, Marcus R, Morize I, Parkar A, Stefany D, Li Y, Vaz RJ, Cirovic DA.
Bioorg Med Chem Lett (2011) 21 : 66 -75
PubMed 21147533 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 60 8.12 10.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1644207 — — 1 10.70
CHEMBL1644214 — — 1 10.30
CHEMBL1644206 — — 1 10.00
CHEMBL1644245 — — 1 9.52
CHEMBL1644213 — — 1 9.52
CHEMBL1644227 — — 1 9.40
CHEMBL1644247 — — 1 9.40
CHEMBL1644211 — — 1 9.40
CHEMBL1644253 — — 1 9.30
CHEMBL1644212 — — 1 9.30
CHEMBL1644208 — — 1 9.30
CHEMBL1644217 — — 1 9.10
CHEMBL1644224 — — 1 9.05
CHEMBL1644255 — — 1 8.64
CHEMBL1644260 — — 1 8.64
CHEMBL1644235 — — 1 8.59
CHEMBL1644256 — — 1 8.59
CHEMBL1644204 — — 1 8.57
CHEMBL1644238 — — 1 8.54
CHEMBL1644216 — — 1 8.44
CHEMBL1644240 — — 1 8.42
CHEMBL1644248 — — 1 8.35
CHEMBL1644210 — — 1 8.30
CHEMBL1644232 — — 1 8.30
CHEMBL1644261 — — 1 8.29
CHEMBL1644225 — — 1 8.22
CHEMBL1644233 — — 1 8.22
CHEMBL1644254 — — 1 8.20
CHEMBL1644252 — — 1 8.15
CHEMBL1644209 — — 1 8.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1644207 — IC50 = 0.01995 nM 10.70
CHEMBL1644214 — IC50 = 0.05012 nM 10.30
CHEMBL1644206 — IC50 = 0.1 nM 10.00
CHEMBL1644245 — IC50 = 0.302 nM 9.52
CHEMBL1644213 — IC50 = 0.302 nM 9.52
CHEMBL1644227 — IC50 = 0.3981 nM 9.40
CHEMBL1644247 — IC50 = 0.3981 nM 9.40
CHEMBL1644211 — IC50 = 0.3981 nM 9.40
CHEMBL1644253 — IC50 = 0.5012 nM 9.30
CHEMBL1644212 — IC50 = 0.5012 nM 9.30
CHEMBL1644208 — IC50 = 0.5012 nM 9.30
CHEMBL1644217 — IC50 = 0.7943 nM 9.10
CHEMBL1644224 — IC50 = 0.8913 nM 9.05
CHEMBL1644260 — IC50 = 2.291 nM 8.64
CHEMBL1644255 — IC50 = 2.291 nM 8.64
CHEMBL1644235 — IC50 = 2.57 nM 8.59
CHEMBL1644256 — IC50 = 2.57 nM 8.59
CHEMBL1644204 — IC50 = 2.692 nM 8.57
CHEMBL1644238 — IC50 = 2.884 nM 8.54
CHEMBL1644216 — IC50 = 3.631 nM 8.44
CHEMBL1644240 — IC50 = 3.802 nM 8.42
CHEMBL1644248 — IC50 = 4.467 nM 8.35
CHEMBL1644210 — IC50 = 5.012 nM 8.30
CHEMBL1644232 — IC50 = 5.012 nM 8.30
CHEMBL1644261 — IC50 = 5.129 nM 8.29
CHEMBL1644225 — IC50 = 6.026 nM 8.22
CHEMBL1644233 — IC50 = 6.026 nM 8.22
CHEMBL1644254 — IC50 = 6.31 nM 8.20
CHEMBL1644252 — IC50 = 7.079 nM 8.15
CHEMBL1644209 — IC50 = 7.079 nM 8.15
CHEMBL1644258 — IC50 = 7.244 nM 8.14
CHEMBL1644226 — IC50 = 7.586 nM 8.12
CHEMBL1644234 — IC50 = 7.762 nM 8.11
CHEMBL1644230 — IC50 = 7.943 nM 8.10
CHEMBL1644239 — IC50 = 8.128 nM 8.09
CHEMBL1644228 — IC50 = 10.0 nM 8.00
CHEMBL1644259 — IC50 = 10.96 nM 7.96
CHEMBL1644231 — IC50 = 12.02 nM 7.92
CHEMBL1644257 — IC50 = 12.88 nM 7.89
CHEMBL1644250 — IC50 = 12.88 nM 7.89
CHEMBL1644246 — IC50 = 14.13 nM 7.85
CHEMBL1644237 — IC50 = 16.98 nM 7.77
CHEMBL1644241 — IC50 = 22.91 nM 7.64
CHEMBL1641628 — IC50 = 25.7 nM 7.59
CHEMBL1644222 — IC50 = 32.36 nM 7.49
CHEMBL1644215 — IC50 = 38.02 nM 7.42
CHEMBL1644223 — IC50 = 40.74 nM 7.39
CHEMBL1644249 — IC50 = 41.69 nM 7.38
CHEMBL1644251 — IC50 = 43.65 nM 7.36
CHEMBL1644236 — IC50 = 54.95 nM 7.26