Assay Detail
Binding
CHEMBL1648957
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Binding affinity to mineralocorticoid receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Tetrahydroquinoline glucocorticoid receptor agonists: discovery of a 3-hydroxyl for improving receptor selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.44 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL258191 | — | — | 1 | 7.68 |
| CHEMBL1644759 | — | — | 1 | 6.10 |
| CHEMBL1644761 | — | — | 1 | 6.05 |
| CHEMBL1644765 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL258191 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL1644759 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1644761 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL1644765 | — | Ki | = | 1200.0 | nM | 5.92 |