Assay Detail
Functional
CHEMBL1648971
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new salvinorin A analogues incorporating natural amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 8.19 | 9.70 |
| Emax | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | 1.0 | 2 | 9.70 |
| CHEMBL1644775 | — | — | 2 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445332 | SALVINORIN A | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1644775 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL1644775 | — | Emax | = | 828.0 | % | - |
| CHEMBL445332 | SALVINORIN A | Emax | = | 703.0 | % | - |