Assay Detail
Binding
CHEMBL1655366
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Inhibition of Leishmania major PTR1
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Leishmania major |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.36 | 4.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650283 | — | — | 1 | 4.66 |
| CHEMBL1650287 | — | — | 1 | 4.54 |
| CHEMBL1650277 | — | — | 1 | 4.51 |
| CHEMBL318275 | — | — | 1 | 4.40 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | 4.30 |
| CHEMBL1650288 | — | — | 1 | 4.05 |
| CHEMBL1650465 | — | — | 1 | 4.03 |
| CHEMBL432942 | — | — | 1 | - |
| CHEMBL1413383 | — | — | 1 | - |
| CHEMBL329785 | — | — | 1 | - |
| CHEMBL1650466 | — | — | 1 | - |
| CHEMBL1650282 | — | — | 1 | - |
| CHEMBL1650274 | — | — | 1 | - |
| CHEMBL595536 | — | — | 1 | - |
| CHEMBL1650263 | — | — | 1 | - |
| CHEMBL147741 | 3-FORMYLINDOLE | — | 1 | - |
| CHEMBL284348 | DALFAMPRIDINE | 4.0 | 1 | - |
| CHEMBL1650237 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650283 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL1650287 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL1650277 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL318275 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL744 | RILUZOLE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL1650288 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL1650465 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL432942 | — | IC50 | = | 212000.0 | nM | - |
| CHEMBL1413383 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL329785 | — | IC50 | = | 1800000.0 | nM | - |
| CHEMBL1650466 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL1650282 | — | IC50 | = | 309000.0 | nM | - |
| CHEMBL1650274 | — | IC50 | = | 2300000.0 | nM | - |
| CHEMBL595536 | — | IC50 | = | 390000.0 | nM | - |
| CHEMBL1650263 | — | IC50 | = | 1000000.0 | nM | - |
| CHEMBL147741 | 3-FORMYLINDOLE | IC50 | = | 1100000.0 | nM | - |
| CHEMBL284348 | DALFAMPRIDINE | IC50 | = | 1900000.0 | nM | - |
| CHEMBL1650237 | — | IC50 | = | 5600000.0 | nM | - |