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Assay Detail

CHEMBL1655367

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Leishmania major PTR1 by Lineweaver-Burk analysis
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Leishmania major
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Pteridine reductase 1 (CHEMBL6194)
Type SINGLE PROTEIN
Organism Leishmania major

Publication

Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.
Ferrari S, Morandi F, Motiejunas D, Nerini E, Henrich S, Luciani R, Venturelli A, Lazzari S, Calò S, Gupta S, Hannaert V, Michels PA, Wade RC, Costi MP.
J Med Chem (2011) 54 : 211 -221
PubMed 21126022 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.17 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1650287 1 5.70
CHEMBL1650283 1 5.70
CHEMBL1650277 1 5.70
CHEMBL318275 1 5.52
CHEMBL744 RILUZOLE 4.0 1 5.40
CHEMBL1650465 1 5.16
CHEMBL1650288 1 5.16
CHEMBL1650466 1 5.05
CHEMBL432942 1 4.80
CHEMBL1650282 1 4.62
CHEMBL1413383 1 4.10
CHEMBL329785 1 -
CHEMBL1650237 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1650287 Ki = 2000.0 nM 5.70
CHEMBL1650283 Ki = 2000.0 nM 5.70
CHEMBL1650277 Ki = 2000.0 nM 5.70
CHEMBL318275 Ki = 3000.0 nM 5.52
CHEMBL744 RILUZOLE Ki = 4000.0 nM 5.40
CHEMBL1650465 Ki = 7000.0 nM 5.16
CHEMBL1650288 Ki = 7000.0 nM 5.16
CHEMBL1650466 Ki = 9000.0 nM 5.05
CHEMBL432942 Ki = 16000.0 nM 4.80
CHEMBL1650282 Ki = 24000.0 nM 4.62
CHEMBL1413383 Ki = 79000.0 nM 4.10
CHEMBL329785 Ki = 143000.0 nM -
CHEMBL1650237 Ki = 436000.0 nM -