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Assay Detail

CHEMBL1657164

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Binding
Inhibition of FKBP12
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein.
Juli C, Sippel M, Jäger J, Thiele A, Weiwad M, Schweimer K, Rösch P, Steinert M, Sotriffer CA, Holzgrabe U.
J Med Chem (2011) 54 : 277 -283
PubMed 21142106 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 7.32 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL126568 1 8.00
CHEMBL109278 1 6.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL126568 Ki = 10.0 nM 8.00
CHEMBL109278 Ki = 230.0 nM 6.64