Assay Detail
Binding
CHEMBL1657166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PPIase activity of human FKBP12 expressed in Escherichia coli by spectrophotometry
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peptidyl-prolyl cis-trans isomerase FKBP1A (CHEMBL1902) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pipecolic acid derivatives as small-molecule inhibitors of the Legionella MIP protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.31 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650949 | — | — | 1 | 7.16 |
| CHEMBL1650947 | — | — | 1 | 6.92 |
| CHEMBL1650948 | — | — | 1 | 6.82 |
| CHEMBL1650946 | — | — | 1 | 6.70 |
| CHEMBL109278 | — | — | 1 | 6.70 |
| CHEMBL1650943 | — | — | 1 | 6.58 |
| CHEMBL1650950 | — | — | 1 | 6.50 |
| CHEMBL1650803 | — | — | 1 | 5.58 |
| CHEMBL1650805 | — | — | 1 | 5.55 |
| CHEMBL1650804 | — | — | 1 | 5.51 |
| CHEMBL1650945 | — | — | 1 | 5.38 |
| CHEMBL1650802 | — | — | 1 | - |
| CHEMBL1650944 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650949 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1650947 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1650948 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1650946 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL109278 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1650943 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1650950 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1650803 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1650805 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1650804 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1650945 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1650802 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL1650944 | — | IC50 | > | 30000.0 | nM | - |