Assay Detail
Binding
CHEMBL1657170
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Inhibition of GST-tagged Jak1 expressed in insect cells using 70 uM ATP
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.22 | 8.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.21 |
| CHEMBL1235315 | — | — | 1 | 6.60 |
| CHEMBL1650953 | — | — | 1 | 6.13 |
| CHEMBL1650955 | — | — | 1 | 6.12 |
| CHEMBL1650951 | — | — | 1 | 5.99 |
| CHEMBL1650954 | — | — | 1 | 5.33 |
| CHEMBL1650956 | — | — | 1 | 5.19 |
| CHEMBL1650952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1235315 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL1650953 | — | IC50 | = | 737.0 | nM | 6.13 |
| CHEMBL1650955 | — | IC50 | = | 754.0 | nM | 6.12 |
| CHEMBL1650951 | — | IC50 | = | 1017.0 | nM | 5.99 |
| CHEMBL1650954 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1650956 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL1650952 | — | IC50 | > | 10000.0 | nM | - |