Assay Detail
Functional
CHEMBL1657353
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Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.04 | 7.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651648 | — | — | 1 | 7.33 |
| CHEMBL1651649 | RAMNODIGIN | 2.0 | 1 | 7.25 |
| CHEMBL1651624 | — | — | 1 | 7.13 |
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651648 | — | IC50 | = | 46.7 | nM | 7.33 |
| CHEMBL1651649 | RAMNODIGIN | IC50 | = | 55.7 | nM | 7.25 |
| CHEMBL1651624 | — | IC50 | = | 74.8 | nM | 7.13 |
| CHEMBL254219 | DIGITOXIN | IC50 | = | 357.0 | nM | 6.45 |