Assay Detail
Binding
CHEMBL1657525
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [33P]S1P from human S1P1R expressed in CHO cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.26 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | -1.0 | 1 | 9.55 |
| CHEMBL194419 | — | — | 1 | 9.22 |
| CHEMBL364899 | — | — | 1 | 8.09 |
| CHEMBL224720 | — | — | 1 | 7.43 |
| CHEMBL196149 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366208 | FTY720-P | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL194419 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL364899 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL224720 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL196149 | — | IC50 | = | 100.0 | nM | 7.00 |