Assay Detail
Functional
CHEMBL1658385
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Antimalarial activity against Plasmodium falciparum D6 assessed as inhibition of [3H] incorporation after 48 hrs by scintillation counter
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.26 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | 3.0 | 1 | 8.85 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | — | 1 | 7.64 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.60 |
| CHEMBL170 | QUININE | 4.0 | 1 | 7.32 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.24 |
| CHEMBL1200699 | DOXYCYCLINE | 4.0 | 1 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307261 | ARTENIMOL | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1235 | DESETHYL AMODIAQUINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL170 | QUININE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1200699 | DOXYCYCLINE | IC50 | = | 13200.0 | nM | 4.88 |