Assay Detail
Functional
CHEMBL1658790
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of new 4β-anilino-4'-O-demethyl-4-desoxypodophyllotoxin derivatives as potential antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 8.40 | 9.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652390 | — | — | 1 | 9.62 |
| CHEMBL1652392 | — | — | 1 | 9.40 |
| CHEMBL1652395 | — | — | 1 | 9.31 |
| CHEMBL1652389 | — | — | 1 | 9.30 |
| CHEMBL1652408 | — | — | 1 | 8.81 |
| CHEMBL1652391 | — | — | 1 | 8.71 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 8.59 |
| CHEMBL1652409 | — | — | 1 | 8.57 |
| CHEMBL1652399 | — | — | 1 | 8.56 |
| CHEMBL1652411 | — | — | 1 | 8.48 |
| CHEMBL1652407 | — | — | 1 | 8.47 |
| CHEMBL1652396 | — | — | 1 | 8.41 |
| CHEMBL1652403 | — | — | 1 | 8.34 |
| CHEMBL1652402 | — | — | 1 | 8.32 |
| CHEMBL1652397 | — | — | 1 | 8.29 |
| CHEMBL1652404 | — | — | 1 | 8.29 |
| CHEMBL1652401 | — | — | 1 | 8.28 |
| CHEMBL1652405 | — | — | 1 | 8.13 |
| CHEMBL1652398 | — | — | 1 | 8.13 |
| CHEMBL1652412 | — | — | 1 | 8.07 |
| CHEMBL1652406 | — | — | 1 | 8.07 |
| CHEMBL1652410 | — | — | 1 | 7.96 |
| CHEMBL1652393 | — | — | 1 | 7.87 |
| CHEMBL1652400 | — | — | 1 | 7.80 |
| CHEMBL1652487 | — | — | 1 | 7.72 |
| CHEMBL1652394 | — | — | 1 | 7.72 |
| CHEMBL1652488 | — | — | 1 | 7.71 |
| CHEMBL1652413 | — | — | 1 | - |
| CHEMBL1652486 | — | — | 1 | - |
| CHEMBL1652489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652390 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL1652392 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1652395 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL1652389 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1652408 | — | IC50 | = | 1.56 | nM | 8.81 |
| CHEMBL1652391 | — | IC50 | = | 1.94 | nM | 8.71 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2.56 | nM | 8.59 |
| CHEMBL1652409 | — | IC50 | = | 2.68 | nM | 8.57 |
| CHEMBL1652399 | — | IC50 | = | 2.75 | nM | 8.56 |
| CHEMBL1652411 | — | IC50 | = | 3.31 | nM | 8.48 |
| CHEMBL1652407 | — | IC50 | = | 3.41 | nM | 8.47 |
| CHEMBL1652396 | — | IC50 | = | 3.91 | nM | 8.41 |
| CHEMBL1652403 | — | IC50 | = | 4.54 | nM | 8.34 |
| CHEMBL1652402 | — | IC50 | = | 4.78 | nM | 8.32 |
| CHEMBL1652397 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL1652404 | — | IC50 | = | 5.11 | nM | 8.29 |
| CHEMBL1652401 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL1652405 | — | IC50 | = | 7.45 | nM | 8.13 |
| CHEMBL1652398 | — | IC50 | = | 7.49 | nM | 8.13 |
| CHEMBL1652412 | — | IC50 | = | 8.43 | nM | 8.07 |
| CHEMBL1652406 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1652410 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1652393 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL1652400 | — | IC50 | = | 15.9 | nM | 7.80 |
| CHEMBL1652487 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL1652394 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1652488 | — | IC50 | = | 19.5 | nM | 7.71 |
| CHEMBL1652413 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL1652486 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL1652489 | — | IC50 | > | 50.0 | nM | - |
| CHEMBL1652490 | — | IC50 | > | 50.0 | nM | - |