Assay Detail
Binding
CHEMBL1660418
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV1 Reverse transcriptase M184V mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.39 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1650290 | — | — | 1 | 6.68 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | -1.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1650290 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL485652 | STAVUDINE TRIPHOSPHATE | Ki | = | 790.0 | nM | 6.10 |