Assay Detail
Binding
CHEMBL1661188
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Inhibition of HIV1 isolate R8 reverse transcriptase K103N mutant after 90 mins by electrochemiluminescence analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Antiviral activity of MK-4965, a novel nonnucleoside reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.83 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL489586 | — | — | 1 | 9.40 |
| CHEMBL308954 | ETRAVIRINE | 4.0 | 1 | 8.89 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.99 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL489586 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL308954 | ETRAVIRINE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL223228 | EFAVIRENZ | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 9300.0 | nM | 5.03 |