Assay Detail
Functional
CHEMBL1661798
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Antiviral activity against BILN 2061-resistant HCV genotype 1b infected in human Huh-9-13 cells assessed as reduction in viral replication after 3 days by quantitative RT-PCR
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.32 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | 3.0 | 1 | 8.40 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 8.40 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | -1.0 | 1 | 7.70 |
| CHEMBL438605 | — | — | 1 | 7.40 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 6.10 |
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1651956 | ALISPORIVIR | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL160 | CYCLOSPORINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL393857 | 4'-AZIDOCYTIDINE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL438605 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL231813 | TELAPREVIR | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL297884 | CILUPREVIR | EC50 | = | 1250.0 | nM | 5.90 |