Assay Detail
Functional
CHEMBL1663311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Immunosuppressive activity in peripheral blood lymphocytes isolated from two individuals assessed as proliferation using [methyl-3H]thymidine by mixed lymphocyte reaction assay
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Lymphocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.43 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652683 | — | — | 1 | 7.92 |
| CHEMBL1652684 | — | — | 1 | 7.92 |
| CHEMBL1652682 | — | — | 1 | 7.40 |
| CHEMBL1652676 | — | — | 1 | 7.40 |
| CHEMBL1652677 | — | — | 1 | 7.30 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 7.27 |
| CHEMBL1652680 | — | — | 1 | 7.16 |
| CHEMBL1652679 | — | — | 1 | 7.05 |
| CHEMBL1652678 | — | — | 1 | 6.64 |
| CHEMBL1652675 | — | — | 1 | 6.57 |
| CHEMBL1652658 | — | — | 1 | 6.52 |
| CHEMBL1652674 | — | — | 1 | 6.46 |
| CHEMBL1652681 | — | — | 1 | 6.42 |
| CHEMBL1652655 | — | — | 1 | 6.31 |
| CHEMBL1652666 | — | — | 1 | 6.16 |
| CHEMBL1652673 | — | — | 1 | 6.16 |
| CHEMBL1652657 | — | — | 1 | 6.16 |
| CHEMBL1652667 | — | — | 1 | 6.16 |
| CHEMBL1652665 | — | — | 1 | 6.10 |
| CHEMBL1652672 | — | — | 1 | 6.04 |
| CHEMBL1652671 | — | — | 1 | 6.02 |
| CHEMBL1652664 | — | — | 1 | 5.52 |
| CHEMBL1652670 | — | — | 1 | 5.45 |
| CHEMBL1652654 | — | — | 1 | 5.37 |
| CHEMBL1652669 | — | — | 1 | 5.36 |
| CHEMBL1652668 | — | — | 1 | 5.36 |
| CHEMBL1652660 | — | — | 1 | 5.31 |
| CHEMBL1643476 | — | — | 1 | - |
| CHEMBL1652663 | — | — | 1 | - |
| CHEMBL1652662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652683 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1652684 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1652682 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1652676 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1652677 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL1652680 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL1652679 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1652678 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL1652675 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL1652658 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1652674 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1652681 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1652655 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL1652657 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1652673 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1652667 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1652666 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1652665 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1652672 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL1652671 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL1652664 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1652670 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL1652654 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL1652669 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL1652668 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL1652660 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1643476 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1652663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1652662 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1652661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1652659 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1652656 | — | IC50 | > | 10000.0 | nM | - |