Assay Detail
Binding
CHEMBL1663324
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Inhibition of PARP1 by chemiluminescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.59 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1652712 | — | — | 1 | 7.22 |
| CHEMBL1652713 | — | — | 1 | 6.40 |
| CHEMBL1652711 | — | — | 1 | 6.16 |
| CHEMBL1652714 | — | — | 1 | - |
| CHEMBL1652715 | — | — | 1 | - |
| CHEMBL1652716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1652712 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1652713 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1652711 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1652714 | — | IC50 | - | — | - | |
| CHEMBL1652715 | — | IC50 | - | — | - | |
| CHEMBL1652716 | — | IC50 | - | — | - |